Changes in Follow-Up Left Ventricular Ejection Fraction Associated With Outcomes in Primary Prevention Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Device Recipients.

ABSTRACT:

Background

Heart failure patients with primary prevention implantable cardioverter-defibrillators (ICD) may experience an improvement in left ventricular ejection fraction (LVEF) over time. However, it is unclear how LVEF improvement affects subsequent risk for mortality and sudden cardiac death.

Objectives

This study sought to assess changes in LVEF after ICD implantation and the implication of these changes on subsequent mortality and ICD shocks.

Methods

We conducted a prospective cohort study of 538 patients with repeated LVEF assessments after ICD implantation for primary prevention of sudden cardiac death. The primary endpoint was appropriate ICD shock defined as a shock for ventricular tachyarrhythmias. The secondary endpoint was all-cause mortality.

Results<

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4522701 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature