Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.

ABSTRACT: In a classic model of mammalian brain formation, precursors of principal glutamatergic neurons migrate radially along radial glia fibers whereas GABAergic interneuron precursors migrate tangentially. These migration modes have significant implications for brain function. Here we used clonal lineage tracing of active radial glia-like neural stem cells in the adult mouse dentate gyrus and made the surprising discovery that proliferating neuronal precursors of glutamatergic granule neurons exhibit significant tangential migration along blood vessels, followed by limited radial migration. Genetic birthdating and morphological and molecular analyses pinpointed the neuroblast stage as the main developmental window when tangential migration occurs. We also developed a partial "whole-mount" dentat

SUBMITTER: Sun GJ 

PROVIDER: S-EPMC4522763 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature