Synchronizing theta oscillations with direct-current stimulation strengthens adaptive control in the human brain.

ABSTRACT: Executive control and flexible adjustment of behavior following errors are essential to adaptive functioning. Loss of adaptive control may be a biomarker of a wide range of neuropsychiatric disorders, particularly in the schizophrenia spectrum. Here, we provide support for the view that oscillatory activity in the frontal cortex underlies adaptive adjustments in cognitive processing following errors. Compared with healthy subjects, patients with schizophrenia exhibited low frequency oscillations with abnormal temporal structure and an absence of synchrony over medial-frontal and lateral-prefrontal cortex following errors. To demonstrate that these abnormal oscillations were the origin of the impaired adaptive control in patients with schizophrenia, we applied noninvasive dc electrical stim

SUBMITTER: Reinhart RM 

PROVIDER: S-EPMC4522782 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature