Proteomics of muscle chronological ageing in post-menopausal women.

ABSTRACT:

Background

Muscle ageing contributes to both loss of functional autonomy and increased morbidity. Muscle atrophy accelerates after 50 years of age, but the mechanisms involved are complex and likely result from the alteration of a variety of interrelated functions. In order to better understand the molecular mechanisms underlying muscle chronological ageing in human, we have undertaken a top-down differential proteomic approach to identify novel biomarkers after the fifth decade of age.

Results

Muscle samples were compared between adult (56 years) and old (78 years) post-menopausal women. In addition to total muscle extracts, low-ionic strength extracts were investigated to remove high abundance myofibrillar proteins and improve the detection of low abundance proteins. Two-d

SUBMITTER: Gueugneau M 

PROVIDER: S-EPMC4523020 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature