Ontology highlight
ABSTRACT:
SUBMITTER: Pandit V
PROVIDER: S-EPMC4523045 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Pandit Vaibhav V Watson Andre A Ren Liyun L Mixon Amanda A Kotha Shiva P SP
Tissue engineering. Part C, Methods 20150428 8
Polycationic nanocomplexes are a robust means for achieving nucleic acid condensation and efficient intracellular gene deliveries. To enhance delivery, a multilayered nanoparticle consisting of a core of electrostatically bound elements was used. These included a histone-mimetic peptides, poly-l-arginine and poly-d-glutamic acid was coated with silicate before surface functionalization with poly-l-arginine. Transfection efficiencies and duration of expression were similar when using green fluore ...[more]