Identification of pathways for bipolar disorder: a meta-analysis.

ABSTRACT:

Importance

Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders.

Objective

To identify biological pathways that contribute to risk for bipolar disorder (BP) using genes with consistent evidence for association in multiple genome-wide association studies (GWAS).

Data sources

Four independent data sets with individual genome-wide data available in July 2011 along with all data sets contributed to the Psychiatric Genomics Consortium Bipolar Group by May 2012. A prior meta-analysis was used as a source for brain gene expression data.

Study selection

The 4 published GWAS were included in the initial sample. All independent BP data sets providing genome-wide data in the Psychiatric Genomics Consortium were incl

SUBMITTER: Nurnberger JI 

PROVIDER: S-EPMC4523227 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature