Preclinical validation of anti-nuclear factor-kappa B therapy to inhibit human vestibular schwannoma growth.

ABSTRACT: Vestibular schwannomas (VSs), the most common tumors of the cerebellopontine angle, arise from Schwann cells lining the vestibular nerve. Pharmacotherapies against VS are almost non-existent. Although the therapeutic inhibition of inflammatory modulators has been established for other neoplasms, it has not been explored in VS. A bioinformatic network analysis of all genes reported to be differentially expressed in human VS revealed a pro-inflammatory transcription factor nuclear factor-kappa B (NF-κB) as a central molecule in VS pathobiology. Assessed at the transcriptional and translational level, canonical NF-κB complex was aberrantly activated in human VS and derived VS cultures in comparison to control nerves and Schwann cells, respectively. Cultured primary VS cells and VS-derived hum

SUBMITTER: Dilwali S 

PROVIDER: S-EPMC4523465 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature