Influence of maternal depression on children's brooding rumination: Moderation by CRHR1 TAT haplotype.

ABSTRACT: There is growing evidence that brooding rumination plays a key role in the intergenerational transmission of major depressive disorder (MDD) and may be an endophenotype for depression risk. However, less is known about the mechanisms underlying this role. Therefore, the goal of the current study was to examine levels of brooding in children of mothers with a history of MDD (n = 129) compared to children of never depressed mothers (n = 126) and to determine whether the variation in a gene known to influence hypothalamic-pituitary-adrenal axis functioning--corticotropin-releasing hormone receptor 1 (CRHR1)--would moderate the link between maternal MDD and children's levels of brooding. We predicted children of mothers with a history of MDD would exhibit higher levels of brooding than childre

SUBMITTER: Woody ML 

PROVIDER: S-EPMC4523466 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature