Genomic expression in non syndromic cleft lip and palate patients: A review.

ABSTRACT: Cleft lip and palate are common congenital anomalies with significant medical, psychological, social, and economic ramifications, affecting one in seven hundred live births. Genetic causes of non syndromic cleft lip and/or palate (NSCLP) include chromosomal rearrangements, genetic susceptibility to teratogenic exposures, and complex genetic contributions of multiple genes. Development of the orofacial clefts in an individual will depend on the interaction of several moderately effecting genes with environmental factors. Several candidate genes have been genotyped in different population types, using case parent trio or case control design; also genes have been sequenced and SNPs have been reported. Quantitative and molecular analysis have shown linkage and association studies to be more re

SUBMITTER: Mehrotra D 

PROVIDER: S-EPMC4523586 | biostudies-literature | 2015 May-Aug

REPOSITORIES: biostudies-literature