Extensive acute axonal damage in pediatric multiple sclerosis lesions.

ABSTRACT:

Objective

Axonal damage occurs early in multiple sclerosis (MS) and contributes to the degree of clinical disability. Children with MS more often show disabling and polyfocal neurological symptoms at disease onset than adults with MS. Thus, axonal damage may differ between pediatric and adult MS patients.

Methods

We analyzed axonal pathology in archival brain biopsy and autopsy samples from 19 children with early MS. Lesions were classified according to demyelinating activity and presence of remyelination. Axonal density and extent of acute axonal damage were assessed using Bielschowsky silver impregnation and immunohistochemistry for amyloid precursor protein (APP), respectively. Axonal injury was correlated with the inflammatory infiltrate as well as clinical characteristi

SUBMITTER: Pfeifenbring S 

PROVIDER: S-EPMC4523885 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature