Links between Anr and Quorum Sensing in Pseudomonas aeruginosa Biofilms.

ABSTRACT:

Unlabelled

In Pseudomonas aeruginosa, the transcription factor Anr controls the cellular response to low oxygen or anoxia. Anr activity is high in oxygen-limited environments, including biofilms and populations associated with chronic infections, and Anr is necessary for persistence in a model of pulmonary infection. In this study, we characterized the Anr regulon in biofilm-grown cells at 1% oxygen in the laboratory strain PAO1 and in a quorum sensing (QS)-deficient clinical isolate, J215. As expected, transcripts related to denitrification, arginine fermentation, high-affinity cytochrome oxidases, and CupA fimbriae were lower in the Δanr derivatives. In addition, we observed that transcripts associated with quorum sensing regulation, iron acquisition and storage, type VI secretio

SUBMITTER: Hammond JH 

PROVIDER: S-EPMC4524035 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature