Identification of YsaP, the Pilotin of the Yersinia enterocolitica Ysa Type III Secretion System.

ABSTRACT:

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Secretins are multimeric outer membrane pore-forming proteins found in complex export systems in Gram-negative bacteria. All type III secretion systems (T3SSs) have a secretin, and one of these is the YsaC secretin of the chromosomally encoded Ysa T3SS of Yersinia enterocolitica. In some cases, pilotin proteins, which are outer membrane lipoproteins, are required for their cognate secretins to multimerize and/or localize to the outer membrane. However, if secretin multimers mislocalize to the inner membrane, this can trigger the protective phage shock protein (Psp) stress response. During a screen for mutations that suppress YsaC toxicity to a psp null strain, we isolated several independent mutations predicted to increase expression of the YE3559 gene within the Ysa pat

SUBMITTER: Rau R 

PROVIDER: S-EPMC4524040 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature