Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses.

ABSTRACT: Epstein-Barr-related herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP), but their host range is not well characterized. Using LCV and B cells from multiple species of Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that growth transformation is restricted to B cells from their own family of hominoids or Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host.

SUBMITTER: Muhe J 

PROVIDER: S-EPMC4524086 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature