Novel Receptor Specificity of Avian Gammacoronaviruses That Cause Enteritis.

ABSTRACT:

Unlabelled

Viruses exploit molecules on the target membrane as receptors for attachment and entry into host cells. Thus, receptor expression patterns can define viral tissue tropism and might to some extent predict the susceptibility of a host to a particular virus. Previously, others and we have shown that respiratory pathogens of the genus Gammacoronavirus, including chicken infectious bronchitis virus (IBV), require specific α2,3-linked sialylated glycans for attachment and entry. Here, we studied determinants of binding of enterotropic avian gammacoronaviruses, including turkey coronavirus (TCoV), guineafowl coronavirus (GfCoV), and quail coronavirus (QCoV), which are evolutionarily distant from respiratory avian coronaviruses based on the viral attachment protein spike (S1). W

SUBMITTER: Ambepitiya Wickramasinghe IN 

PROVIDER: S-EPMC4524090 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature