Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins.

ABSTRACT:

Unlabelled

Human herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are large-genome DNA viruses that establish a persistent infection in sensory neurons and commonly manifest with recurring oral or genital erosions that transmit virus. HSV encodes 12 predicted glycoproteins that serve various functions, including cellular attachment, entry, and egress. Glycoprotein G is currently the target of an antibody test to differentiate HSV-1 from HSV-2; however, this test has shown reduced capacity to differentiate HSV strains in East Africa. Until the recent availability of 26 full-length HSV-1 and 36 full-length HSV-2 sequences, minimal comparative information was available for these viruses. In this study, we use a variety of sequence analysis methods to compare all available sequence dat

SUBMITTER: Lamers SL 

PROVIDER: S-EPMC4524236 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature