Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience.

ABSTRACT: The intuitive association between self-focused rumination in major depressive disorder (MDD) and the self-referential operations performed by the brain's default-mode network (DMN) has prompted interest in examining the role of the DMN in MDD. In this article, we present meta-analytic findings showing reliably increased functional connectivity between the DMN and subgenual prefrontal cortex (sgPFC)-connectivity that often predicts levels of depressive rumination. We also present meta-analytic findings that, while there is reliably increased regional cerebral blood flow in sgPFC in MDD, no such abnormality has been reliably observed in nodes of the DMN. We then detail a model that integrates the body of research presented. In this model, we propose that increased functional connectivity bet

SUBMITTER: Hamilton JP 

PROVIDER: S-EPMC4524294 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature