Metabolomic Evaluation of Neutrophilic Airway Inflammation in Cystic Fibrosis.

ABSTRACT:

Background

Metabolomic evaluation of cystic fibrosis (CF) airway secretions could identify metabolites and metabolic pathways involved in neutrophilic airway inflammation that could serve as biomarkers and therapeutic targets.

Methods

Mass spectrometry (MS)-based metabolomics was performed on a discovery set of BAL fluid samples from 25 children with CF, and targeted MS methods were used to identify and quantify metabolites related to neutrophilic inflammation. A biomarker panel of these metabolites was then compared with neutrophil counts and clinical markers in independent validation sets of lavage from children with CF and adults with COPD compared with control subjects.

Results

Of the 7,791 individual peaks detected by positive-mode MS metabolomics discovery profi

SUBMITTER: Esther CR 

PROVIDER: S-EPMC4524329 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature