Association of genetic variants with rapid fibrosis: progression after liver transplantation for hepatitis C.

ABSTRACT:

Background

Recurrence of hepatitis C, the main indication for liver transplantation in the United States, leads to rapid fibrosis progression and worse outcomes compared to other indications. While clinical variables play a role, they are insufficient to explain all inter-patient variability in posttransplant fibrosis progression. Genetic factors associated with hepatitis C virus (HCV) outcomes have been identified, but limited studies have been conducted in the context of HCV-related liver transplantation. Therefore, the purpose of this study was to examine candidate genes related to the immune response and rate of fibrosis in subjects undergoing liver transplantation for HCV.

Methods

One hundred twelve recipients with detailed posttransplant fibrosis and clinical informati

SUBMITTER: Layden JE 

PROVIDER: S-EPMC4524502 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature