Enzymatic Glucose Sensor Compensation for Variations in Ambient Oxygen Concentration.

ABSTRACT: Due to the increasing prevalence of diabetes, research toward painless glucose sensing continues. Oxygen sensitive phosphors with glucose oxidase (GOx) can be used to determine glucose levels indirectly by monitoring oxygen consumption. This is an attractive combination because of its speed and specificity. Packaging these molecules together in "smart materials" for implantation will enable non-invasive glucose monitoring. As glucose levels increase, oxygen levels decrease; consequently, the luminescence intensity and lifetime of the phosphor increase. Although the response of the sensor is dependent on glucose concentration, the ambient oxygen concentration also plays a key role. This could lead to inaccurate glucose readings and increase the risk of hyper- or hypoglycemia. To mitigate th

SUBMITTER: Collier BB 

PROVIDER: S-EPMC4524553 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature