Ontology highlight
ABSTRACT:
SUBMITTER: Nath AK
PROVIDER: S-EPMC4524786 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cell reports 20150205 5
Virtually all organisms seek to maximize fitness by matching fuel availability with energy expenditure. In vertebrates, glucose homeostasis is central to this process, with glucose levels finely tuned to match changing energy requirements. To discover new pathways regulating glucose levels in vivo, we performed a large-scale chemical screen in live zebrafish and identified the small molecule alexidine as a potent glucose-lowering agent. We found that alexidine inhibits the PTEN-like mitochondria ...[more]