Effect of Vitamin D3 Supplementation in Black and in White Children: A Randomized, Placebo-Controlled Trial.

ABSTRACT:

Context

Dosages of vitamin D necessary to prevent or treat vitamin D deficiency in children remain to be clarified.

Objective

To determine the effects of vitamin D3 1000 IU/d on serum 25-hydroxyvitamin D [25(OH)D], PTH, and markers of bone turnover (osteocalcin and collagen type 1 cross-linked C-telopeptide) in black children and white children, and to explore whether there is a threshold level of 25(OH)D associated with maximal suppression of serum PTH concentration.

Design

Healthy 8- to 14-year-old Pittsburgh-area black (n = 84) and white (n = 73) children not receiving vitamin supplements, enrolled from October through March from 2008 through 2011, were randomized to vitamin D3 1000 IU or placebo daily for 6 months.

Results

The mean baseline concentration of

SUBMITTER: Rajakumar K 

PROVIDER: S-EPMC4524986 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature