Adipose Tissue Redistribution and Ectopic Lipid Deposition in Active Acromegaly and Effects of Surgical Treatment.

ABSTRACT:

Context

GH and IGF-I have important roles in the maintenance of substrate metabolism and body composition. However, when in excess in acromegaly, the lipolytic and insulin antagonistic effects of GH may alter adipose tissue (AT) deposition.

Objectives

The purpose of this study was to examine the effect of surgery for acromegaly on AT distribution and ectopic lipid deposition in liver and muscle.

Design

This was a prospective study before and up to 2 years after pituitary surgery.

Setting

The setting was an academic pituitary center.

Patients

Participants were 23 patients with newly diagnosed, untreated acromegaly.

Main outcome measures

We determined visceral (VAT), subcutaneous (SAT), and intermuscular adipose tissue (IMAT), and skeletal muscle co

SUBMITTER: Reyes-Vidal CM 

PROVIDER: S-EPMC4524994 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature