Duration of Diabetes Predicts Aortic Pulse Wave Velocity and Vascular Events in Alstrom Syndrome.

ABSTRACT:

Context

Alström syndrome is characterized by increased risk of cardiovascular disease from childhood.

Objective

To explore the association between risk factors for cardiovascular disease, aortic pulse wave velocity, and vascular events in Alström syndrome.

Design

Cross-sectional analyses with 5-year follow-up.

Setting

The UK NHS nationally commissioned specialist clinics for Alström syndrome.

Patients

Thirty-one Alström patients undertook vascular risk assessment, cardiac studies, and aortic pulse wave velocity measurement. Subsequent clinical outcomes were recorded.

Interventions

Insulin resistance was treated with lifestyle intervention and metformin, and diabetes with the addition of glitazones, glucagon-like peptide 1 agonists, and/or insulin.

SUBMITTER: Paisey RB 

PROVIDER: S-EPMC4525001 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature