RAAS Activation Is Associated With Visceral Adiposity and Insulin Resistance Among HIV-infected Patients.

ABSTRACT:

Context

Little is known about renin-angiotensin-aldosterone system (RAAS) activation in relationship to visceral adipose tissue (VAT) accumulation in HIV-infected patients, a population at significant risk for insulin resistance and other metabolic disease.

Design

Twenty HIV and 10 non-HIV-infected subjects consumed a standardized low sodium or liberal sodium diet to stimulate or suppress the RAAS, respectively. RAAS parameters were evaluated in response to each diet and a graded angiotensin II infusion. Further analyses were performed after groups were substratified by median VAT measured by magnetic resonance imaging.

Results

Aldosterone concentrations during the low-sodium diet were higher in HIV than non-HIV-infected subjects [13.8 (9.7, 30.9) vs 9.2 (7.6, 13.6) n

SUBMITTER: Srinivasa S 

PROVIDER: S-EPMC4525005 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature