Myocardial Fat Accumulation Is Independent of Measures of Insulin Sensitivity.

ABSTRACT:

Background

Myocardial steatosis, an independent predictor of diastolic dysfunction, is frequently present in type 2 diabetes mellitus. High free fatty acid flux, hyperglycemia, and hyperinsulinemia may play a role in myocardial steatosis. There are no prior studies examining the relationship between insulin sensitivity (antilipolytic and glucose disposal actions of insulin) and cardiac steatosis.

Objective

Using a cross-sectional study design of individuals with and without metabolic syndrome (MetSyn), we examined the relationships between cardiac steatosis and the sensitivity of the antilipolytic and glucose disposal actions of insulin.

Methods

Pericardial fat (PF) volume, intramyocardial and hepatic fat (MF and HF) content, visceral fat (VF) and sc fat content were

SUBMITTER: Muniyappa R 

PROVIDER: S-EPMC4525006 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature