Ontology highlight
ABSTRACT:
SUBMITTER: Atack JM
PROVIDER: S-EPMC4525171 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature communications 20150728
Non-typeable Haemophilus influenzae contains an N(6)-adenine DNA-methyltransferase (ModA) that is subject to phase-variable expression (random ON/OFF switching). Five modA alleles, modA2, modA4, modA5, modA9 and modA10, account for over two-thirds of clinical otitis media isolates surveyed. Here, we use single molecule, real-time (SMRT) methylome analysis to identify the DNA-recognition motifs for all five of these modA alleles. Phase variation of these alleles regulates multiple proteins includ ...[more]