ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function.

ABSTRACT: Neural vascular barrier is essential for the life of multicellular organisms, and its impairment by tissue hypoxia is known to be a central of pathophysiology accelerating the progression of various intractable neural diseases. Therefore, the molecules involved in hypoxia-induced impairment of vascular barrier can be the targets to establish new therapies for intractable diseases. Here, we demonstrate that a disintegrin and metalloproteinases (ADAMs) 12 and 17 expressed in endothelial cells are the molecules responsible for the impairment of neural vascular barrier by hypoxia. Brain microvascular endothelial cells in vitro lost their barrier properties immediately after hypoxic stimulation through diminished localization of claudin-5, a tight junction molecule, on cell membranes. Hypoxic d

SUBMITTER: Cui D 

PROVIDER: S-EPMC4525292 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature