Metabolome-Wide Association Study of Primary Open Angle Glaucoma.

ABSTRACT:

Purpose

To determine if primary open-angle glaucoma (POAG) patients can be differentiated from controls based on metabolic characteristics.

Methods

We used ultra-high resolution mass spectrometry with C18 liquid chromatography for metabolomic analysis on frozen plasma samples from 72 POAG patients and 72 controls. Metabolome-wide Spearman correlation was performed to select differentially expressed metabolites (DEM) correlated with POAG. We corrected P values for multiple testing using Benjamini and Hochberg false discovery rate (FDR). Hierarchical cluster analysis (HCA) was used to depict the relationship between participants and DEM. Differentially expressed metabolites were matched to the METLIN metabolomics database; both DEM and metabolites significantly correlating wit

SUBMITTER: Burgess LG 

PROVIDER: S-EPMC4525636 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature