The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia.

ABSTRACT:

Purpose

In order to better understand whether white matter structural deficits are present in strabismic amblyopia, we performed a survey of the tissue properties of 28 major white matter tracts using diffusion and quantitative magnetic resonance imaging approaches.

Methods

We used diffusion-based tensor modeling and a new quantitative T1 protocol to measure fractional anisotropy (FA), mean diffusivity (MD), and myelin-sensitive T1 values. We surveyed tracts in the occipital lobe, including the vertical occipital fasciculus (VOF)-a newly rediscovered tract that bridges dorsal and ventral areas of the occipital lobe, as well as tracts across the rest of the brain.

Results

Adults with long-standing strabismic amblyopia show tract-specific elevations in MD. We rank-order

SUBMITTER: Duan Y 

PROVIDER: S-EPMC4525637 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature