Overexpression of PROM1 (CD133) confers poor prognosis in non-small cell lung cancer.

ABSTRACT: The surface marker PROM1 is considered one of the most important marker of tumor-initiating cells, and its high expression is believed to be an adverse prognostic factor in gliomas, medulloblastoma and in other malignancies. The aims of our research were to explore the expression profile of the PROM1 in non-small cell lung cancer (NSCLC) and to assess its possible role as a prognostic factor. The protein expression profiles were determined via immunohistochemical staining assay. The clinical prognostic values of protein expression were investigated with univariate and multivariate survival analysis. The quantitative variable PROM1 expression was dichotomized according to the best cutoff value obtained by the receiver operating characteristics (ROC) analysis. The protein level of PROM1 of N

SUBMITTER: Qiu ZX 

PROVIDER: S-EPMC4525874 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature