Association between CTLA-4 gene polymorphism and ankylosing spondylitis: a case-control study.

ABSTRACT:

Aims

The aim of our study was to evaluate the association between CTLA-4 polymorphisms (+49A/G, -318C/T and CT60A/G) and ankylosing spondylitis (AS) susceptibility.

Methods

A total of 120 AS cases and healthy controls, matched on the age and gender, were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) were used to determine the gentypes of +49A/G, -318C/T and CT60A/G polymorphisms. Genotype distribution in control group was assessed by Hardy Weinberg Equilibrium (HWE) test. Odds ratio (OR) with 95% confidence interval (95% CI) were adopted to evaluate the relationship of CTLA-4 polymorphisms and AS susceptibility.

Results

In our study, genotype distribution of the three polymorphisms in control group was consistent

SUBMITTER: Wang NG 

PROVIDER: S-EPMC4525980 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature