Relevance between HLA-DP gene rs2281388 polymorphism and hepatocellular carcinoma risk.

ABSTRACT:

Purpose

We carried out this study to find out the relevance between rs2281388 T/C polymorphism of human leukocyte antigen (HLA) gene and hepatocellular carcinoma (HCC) risk in Chinese Han population.

Methods

The method of polymerase chain reaction (PCR) was applied to amplify the genomic DNA. Then the PCR products were sequenced to test the HLA-DP gene rs2281388T/C polymorphism of the case and control groups. Odds ratios (ORs) and 95% confidence interval (95% CIs) were utilized to evaluate the potential correlation between rs2281388 variants and HCC risk.

Results

We analyzed the rs2281388 polymorphism distribution among the clinical pathological features. The results showed that there existed a significant statistic correlation between rs2281388T/C polymorphism of HLA

SUBMITTER: Liu F 

PROVIDER: S-EPMC4525982 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature