Identification of genes associated with laryngeal squamous cell carcinoma samples based on bioinformatic analysis.

ABSTRACT: The present study aimed to investigate the differentially expressed genes (DEGs) between laryngeal squamous cell carcinoma (LSCC) samples and non‑neoplastic laryngeal squamous cell samples, and the underlying biological mechanism. Gene expression profile data of GSE51985 and GSE10288 were obtained from the Gene Expression Omnibus database. The DEGs between the LSCC and normal samples were identified using the rowtest function in the genefilter package. Hierarchical clustering for DEGs was performed to confirm the distinction between the identified DEGs, and Gene Ontology term and pathway enrichment analyses were performed to determine the underlying function of the DEGs. In addition, protein‑protein interaction networks were established to investigate the interactive mechanism of the DEGs.

SUBMITTER: Yang B 

PROVIDER: S-EPMC4526082 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature