Noninvasive fetal sex determination using cell-free fetal DNA: a systematic review and meta-analysis.

ABSTRACT:

Context

Noninvasive prenatal determination of fetal sex using cell-free fetal DNA provides an alternative to invasive techniques for some heritable disorders. In some countries this testing has transitioned to clinical care, despite the absence of a formal assessment of performance.

Objective

To document overall test performance of noninvasive fetal sex determination using cell-free fetal DNA and to identify variables that affect performance.

Data sources

Systematic review and meta-analysis with search of PubMed (January 1, 1997-April 17, 2011) to identify English-language human studies reporting primary data. References from review articles were also searched.

Study selection and data extraction

Abstracts were read independently to identify studies reporting p

SUBMITTER: Devaney SA 

PROVIDER: S-EPMC4526182 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature