Diuretics vs. placebo for postpartum blood pressure control in preeclampsia (DIUPRE): a randomized clinical trial.

ABSTRACT:

Background

Hypertension affects about 10% of pregnancies and is responsible for both maternal and neonatal devastating complications such as eclampsia, HELLP syndrome, prematurity and maternal and neonatal death. The resolution of the disease occurs in the first twelve weeks postpartum. The behavior of blood pressure and occurrence of very high blood pressure episodes among women with severe preeclampsia is related to remodeling of the dynamics of body fluids with consequent increase in intravascular volume. The persistence of hypertension in critical levels results in increased puerperal morbidity.

Objectives

To evaluate the effectiveness of furosemide in accelerating blood pressure recovery among women with severe preeclampsia.

Methods/design

A triple-masked placebo

SUBMITTER: Cursino T 

PROVIDER: S-EPMC4526282 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature