The prognostic significance of anti-angiogenesis therapy in ovarian cancer: a meta-analysis.

ABSTRACT:

Objective

The prognostic value of anti-angiogenesis therapy in ovarian cancer patients is currently under debate. In this study, we assessed the effects of anti-angiogenesis therapy on the progression free survival (PFS) and overall survival (OS) of ovarian cancer patients.

Materials and methods

PubMed was searched to identify relevant studies that evaluated the therapeutic value of anti-angiogenic agents in ovarian cancer (the final search was current to Dec. 13th 2014). Reviews of each study were conducted, and the data were extracted. The primary outcomes that were analysed were progression free survival (PFS) and overall survival (OS). The pooled hazard ratio (HR) and 95 % confidence intervals (CIs) were calculated using the random and fixed-effects models, and subgroup

SUBMITTER: Li J 

PROVIDER: S-EPMC4526298 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature