Biodynamic performance of hyaluronic acid versus synovial fluid of the knee in osteoarthritis.

ABSTRACT: Hyaluronic acid (HA), a natural biomaterial present in healthy joints but depleted in osteoarthritis (OA), has been employed clinically to provide symptomatic relief of joint pain. Joint movement combined with a reduced joint lubrication in osteoarthritic knees can result in increased wear and tear, chondrocyte apoptosis, and inflammation, leading to cascading cartilage deterioration. Therefore, development of an appropriate cartilage model that can be evaluated for its friction properties with potential lubricants in different conditions is necessary, which can closely resemble a mechanically induced OA cartilage. Additionally, a comparison of different models with and without endogenous lubricating surface zone proteins, such as PRG4 promotes a well-rounded understanding of cartilage lub

SUBMITTER: Corvelli M 

PROVIDER: S-EPMC4526414 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature