Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research.

ABSTRACT: Chronic stress (CS) was reported to associate with many complex diseases and stress-related diseases show strong comorbidity; however, molecular analyses have not been performed to date to evaluate common stress-induced biological processes across these diseases. We utilized networks constructed by genes from seven genetic databases of stress-related diseases or systems to explore the common mechanisms. Genes were connected based on the interaction information of proteins they encode. A common sub-network constructed by 561 overlapping genes and 8863 overlapping edges among seven networks was identified and it provides a common gene module among seven stress-related diseases/systems. This module is significantly overlapped with network that constructed by genes from the CS gene database. 3

SUBMITTER: Guo L 

PROVIDER: S-EPMC4526881 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature