Association between Genetic Polymorphisms in DEFB1 and Susceptibility to Digestive Diseases.

ABSTRACT:

Background

Aberrant expression of defensins is implicated in the pathogenesis of digestive diseases. However, the contribution of specific defensins and the influence of their genetic polymorphisms on the progression of digestive diseases remain controversial. In the present meta-analysis, we investigated the association between DEFB1 SNPs and the susceptibility to digestive diseases.

Material and methods

Case-control studies that reported the correlation between DEFB1 SNPs and the susceptibility to digestive diseases were identified through electronic databases searches, and high-quality studies that satisfied our inclusion criteria were selected for this meta-analysis. Statistical analyses were performed utilizing STATA software version 12.0.

Results

The present met

SUBMITTER: Huang YP 

PROVIDER: S-EPMC4527116 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature