Association between SLC30A8 rs13266634 Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis.

ABSTRACT:

Background

Accumulating but inconsistent data about the role of rs13266634 variant of SLC30A8 in type 2 diabetes have been reported, partly due to small sample sizes and non-identical ethnicity.

Material and methods

We searched PubMed and Cochrane Library to identify eligible studies and extract data of baseline characteristics, genotype count, odds ratio (OR), and 95% confidence interval (CI). Both adjusted OR with 95% CI and genotype counts were employed to assess the association. Genotype data were further pooled to provide estimates under different genetic models and the most appropriate model was determined. Sensitivity and cumulative analysis were conducted to assure the strength of results.

Results

Fifty-five datasets of 39 studies (including 38 of 24 with geno

SUBMITTER: Cheng L 

PROVIDER: S-EPMC4527121 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature