Nanoparticle-based brachytherapy spacers for delivery of localized combined chemoradiation therapy.

ABSTRACT:

Purpose

In radiation therapy (RT), brachytherapy-inert source spacers are commonly used in clinical practice to achieve high spatial accuracy. These implanted devices are critical technical components of precise radiation delivery but provide no direct therapeutic benefits.

Methods and materials

Here we have fabricated implantable nanoplatforms or chemoradiation therapy (INCeRT) spacers loaded with silica nanoparticles (SNPs) conjugated containing a drug, to act as a slow-release drug depot for simultaneous localized chemoradiation therapy. The spacers are made of poly(lactic-co-glycolic) acid (PLGA) as matrix and are physically identical in size to the commercially available brachytherapy spacers (5 mm × 0.8 mm). The silica nanoparticles, 250 nm in diameter, were conjugated

SUBMITTER: Kumar R 

PROVIDER: S-EPMC4527168 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature