Ontology highlight
ABSTRACT:
SUBMITTER: Berry RL
PROVIDER: S-EPMC4527280 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Disease models & mechanisms 20150514 8
Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour suppressor gene. Here, we describe a developmental series of mouse models with conditional loss of Wt1 in different stages of nephron development before and after the mesenchymal-to-epithelial transition (MET). We demonstrate that Wt1 is essential for no ...[more]