The landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma.

ABSTRACT:

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Human prostate cancer is known to harbor recurrent genomic aberrations consisting of chromosomal losses, gains, rearrangements, and mutations that involve oncogenes and tumor suppressors. Genetically engineered mouse (GEM) models have been constructed to assess the causal role of these putative oncogenic events and provide molecular insight into disease pathogenesis. While GEM models generally initiate neoplasia by manipulating a single gene, expression profiles of GEM tumors typically comprise hundreds of transcript alterations. It is unclear whether these transcriptional changes represent the pleiotropic effects of single oncogenes, and/or cooperating genomic or epigenomic events. Therefore, it was determined whether structural chromosomal alterations occur in GEM mode

SUBMITTER: Bianchi-Frias D 

PROVIDER: S-EPMC4527302 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature