B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis.

ABSTRACT:

Rationale

B cells contribute to atherosclerosis through subset-specific mechanisms. Whereas some controversy exists about the role of B-2 cells, B-1a cells are atheroprotective because of secretion of atheroprotective IgM antibodies independent of antigen. B-1b cells, a unique subset of B-1 cells that respond specifically to T-cell-independent antigens, have not been studied within the context of atherosclerosis.

Objective

To determine whether B-1b cells produce atheroprotective IgM antibodies and function to protect against diet-induced atherosclerosis.

Methods and results

We demonstrate that B-1b cells are sufficient to produce IgM antibodies against oxidation-specific epitopes on low-density lipoprotein both in vitro and in vivo. In addition, we demonstrate that B-

SUBMITTER: Rosenfeld SM 

PROVIDER: S-EPMC4527334 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature