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Biological challenges to effective vaccines in the developing world.

ABSTRACT: The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy.

SUBMITTER: Grassly NC 

PROVIDER: S-EPMC4527384 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Biological challenges to effective vaccines in the developing world.

Grassly Nicholas C NC   Kang Gagandeep G   Kampmann Beate B  

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20150601 1671

The reason for holding a meeting to discuss biological challenges to vaccines is simple: not all vaccines work equally well in all settings. This special issue reviews the performance of vaccines in challenging environments, summarizes current thinking on the reasons why vaccines underperform and considers what approaches are necessary to understand the heterogeneity in responses and to improve vaccine immunogenicity and efficacy. ...[more]

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