Multigene predictors of tacrolimus exposure in kidney transplant recipients.

ABSTRACT:

Aim

Determine the effect of the genetic variants beyond CYP3A5*3 on tacrolimus disposition.

Patients & methods

We studied genetic correlates of tacrolimus trough concentrations with POR*28, CYP3A4*22 and ABCC2 haplotypes in a large, ethnically diverse kidney transplant cohort (n = 2008).

Results

Subjects carrying one or more CYP3A5*1 alleles had lower tacrolimus trough concentrations (p = 9.2 × 10(-75)). The presence of one or two POR*28 alleles was associated with a 4.63% reduction in tacrolimus trough concentrations after adjusting for CYP3A5*1 and clinical factors (p = 0.037). In subset analyses, POR*28 was significant only in CYP3A5*3/*3 carriers (p = 0.03). The CYP3A4*22 variant and the ABBC2 haplotypes were not associated.

Conclusion

This study confirmed

SUBMITTER: Pulk RA 

PROVIDER: S-EPMC4527535 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature