Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer.

ABSTRACT: Histamine functionalized block copolymers based on poly(allyl glycidyl ether)-b-poly(ethylene oxide) (PAGE-b-PEO) were prepared with different ratios of histamine and octyl or benzyl groups using UV-initiated thiol-ene click chemistry. At neutral pH, the histamine units are uncharged and hydrophobic, while in acidic environments, such as in the endosome, lysosomes, or extracellular sites of tumours, the histamine groups are positively charged and hydrophilic. pH responsible polymer drug delivery systems is a promising route to site specific delivery of drugs and offers the potential to avoid side effects of systemic treatment. Our detailed in vitro experiments of the efficacy of drug delivery and the intracellular localization characteristics of this library of NPs in

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4527560 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature