Environmental Interactions and Epistasis Are Revealed in the Proteomic Responses to Complex Stimuli.

ABSTRACT: Ultimately, the genotype of a cell and its interaction with the environment determine the cell's biochemical state. While the cell's response to a single stimulus has been studied extensively, a conceptual framework to model the effect of multiple environmental stimuli applied concurrently is not as well developed. In this study, we developed the concepts of environmental interactions and epistasis to explain the responses of the S. cerevisiae proteome to simultaneous environmental stimuli. We hypothesize that, as an abstraction, environmental stimuli can be treated as analogous to genetic elements. This would allow modeling of the effects of multiple stimuli using the concepts and tools developed for studying gene interactions. Mirroring gene interactions, our results show that environmen

SUBMITTER: Samir P 

PROVIDER: S-EPMC4527715 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature