The Force at the Tip--Modelling Tension and Proliferation in Sprouting Angiogenesis.

ABSTRACT: Sprouting angiogenesis, where new blood vessels grow from pre-existing ones, is a complex process where biochemical and mechanical signals regulate endothelial cell proliferation and movement. Therefore, a mathematical description of sprouting angiogenesis has to take into consideration biological signals as well as relevant physical processes, in particular the mechanical interplay between adjacent endothelial cells and the extracellular microenvironment. In this work, we introduce the first phase-field continuous model of sprouting angiogenesis capable of predicting sprout morphology as a function of the elastic properties of the tissues and the traction forces exerted by the cells. The model is very compact, only consisting of three coupled partial differential equations, and has the cl

SUBMITTER: Santos-Oliveira P 

PROVIDER: S-EPMC4527825 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature