Influence of ageing and essential amino acids on quantitative patterns of troponin T alternative splicing in human skeletal muscle.

ABSTRACT: Ageing is associated with a loss of skeletal muscle performance, a condition referred to as sarcopenia. In part, the age-related reduction in performance is due to a selective loss of muscle fiber mass, but mass-independent effects have also been demonstrated. An important mass-independent determinant of muscle performance is the pattern of expression of isoforms of proteins that participate in muscle contraction (e.g., the troponins). In the present study, we tested the hypothesis that ageing impairs alternative splicing of the pre-mRNA encoding fast skeletal muscle troponin T (TNNT3) in human vastus lateralis muscle. Furthermore, we hypothesized that resistance exercise alone or in combination with consumption of essential amino acids would attenuate age-associated effects on TNNT3 alter

SUBMITTER: Coble J 

PROVIDER: S-EPMC4527890 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature